Together, they enable Apton to accurately detect a single cancer molecule. And do it when it matters most.
At its core, the preparation of the sample is uncomplicated, using inexpensive components, and requiring only basic lab skills.
Our proprietary high-speed, super-resolution scanners can resolve molecules that are separated by less than the wavelength of light.
APT Error Correction repeatedly measures the same target to assure accuracy and confidence.
Apton has demonstrated single molecule detection on a simple biochip using proprietary surface chemistry that irreversibly attaches molecules to the surface. Individual cancer biomarkers, whether DNA, RNA, or protein, are detected using our high-speed super-resolution imaging system. To achieve the desired specificity, Apton uses its patented APT Error Correction technology leveraging repeated cycles of probing coupled with a color-swap probe strategy to build biomarker specific molecular barcodes. The simplicity of the sample prep, the sensitivity of the detection, and the specificity of the error correction enable the next-generation cancer diagnostic engine.
Apton can also sequence DNA using the same hardware stack. And because of Apton’s proprietary “self assembly” technology, flow cells are filled with DNA concatemers from a traditional NGS library at a density unmatched in industry. The greater density allows for unprecedented scale which enables genomes to be cost-effectively sequenced, allowing screening for inherited disease risks for cancer and beyond. Targeted gene sequencing is also possible to complement the single molecule detection capabilities. Apton’s high-density DNA sequencing will lower the cost of sequencing 100 fold enabling genetic risk identification for entire populations.
Apton’s Pleasanton, California-based laboratory houses several of the unparalleled, purpose built high-speed super-resolution imaging systems, which are at the heart of the technology. Three key patent families protect this unique technology: optical systems, single-molecule detection and super-resolution sequencing. Relying on both sophisticated optics and image processing algorithms, this system resolves objects with spacing approaching the wavelength of light, with acceleration tracking and real-time image stabilization to enable rapid data collection at unprecedented data densities. Machine learning algorithms enhance system performance. The proprietary flow cell design focuses on cost-reduction, allowing value to be shared across the diagnostic testing supply chain.